1 talking about this. David Horn's 220 research works with 6,658 citations and 4,337 reads, including: Suramin exposure alters cellular metabolism and mitochondrial energy production in African trypanosomes We have a record for a David A Horn living at an address in Dundee DD5. David Horn's 225 research works with 7,084 citations and 4,192 reads, including: Veterinary trypanocidal benzoxaboroles are peptidase-activated prodrugs 1. DNA repair is required to replace the active Variant Surface Glycoprotein (VSG) gene with a new VSG and VSG expression is monoallelic (at a telomere) so our work in this area focuses on understanding mechanisms of DNA recombination and monotelomeric gene expression. Vezi profilurile persoanelor care poartă numele de David Horn. Rudd SG, Glover L, Jozwiakowski SK, Horn D and Doherty AJ (2013) PPL2 translesion polymerase is essential for the completion of chromosomal DNA replication in the African trypanosome.Mol. Civil/Structural Mr. Horne is a hands-on engineer. Our exploitation of genome sequence data is underpinned by technology development. Glover L, McCulloch R andHorn D. (2008) Sequence homology and microhomology dominate chromosomal double-strand break repair in African trypanosomes. In a paper published in Nature Microbiology, David Horn, Professor of Parasite Molecular biology in the Wellcome Centre for Anti-Infectives Research, said that the findings represent a major advance. Toxicity has always been an issue but these drugs have proven to be both effective and quite durable. 505:681-685. Grow 2.5 x 10 7 cells for each electroporation. Glover L, Jun J andHorn D. (2011) Microhomology mediated deletion and gene conversion in African trypanosomes. Helen Mirren to Receive Career Achievement Honor at Aarp The Magazine's Movies For Grownups Awards Discovery - the University of Dundee Research Portal contact form. There are 500+ professionals named "David Horne", who use LinkedIn to exchange information, ideas, and opportunities. Suramin uptake was shown to be via receptor (ISG75)-mediated endocytosis while an aquaglyceroporin (AQP2) controls melarsoprol-pentamidine cross-resistance; AQP2 has now also been linked to clinical cases of melarsoprol resistance. The University of Dundee’s Professor David Horn has received a prestigious award in recognition of his contribution to global efforts to overcome the disease known as African sleeping sickness. Biological Chemistry and Drug Discovery, School of Life Sciences. David Horn, Professor of Parasite Molecular Biology and Deputy Director of WCAIR and the Division of Biological Chemistry and Drug Discovery was recently awarded the William Trager award by the American Committee of Molecular, Cellular and Immunoparasitology (ACMCIP). Mattie Pawlowic (Participant) & David Horn (Participant) 6 Mar 2019 → 7 Mar 2019. We have found at least 200 people in the UK with the name David Horn. University of Dundee VEX1 controls the allelic exclusion required for antigenic variation in trypanosomes Glover, Lucy; Hutchinson, Sebastian; Alsford, Sam; Horn, David USA.113:7225-30. During that time I’ve created and contributed to marketing, advertising, design and product development work across a multitude of industries and agencies and for organizations in every stage from startup to legacy. Over the last seventeen years, I’ve had the great fortune to learn from and work with amazing and brilliant people. His research is focused on antigenic variation, drug action and resistance and the application of genetic screens to the African trypanosome, Trypanosoma brucei. (2011) High throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome. The University of Dundee’s Professor David Horn has received a prestigious award in recognition of his contribution to global efforts to overcome the disease known as African sleeping sickness. Engineering Field. Professor Ian Gilbert Head of Chemistry Drug Discovery Unit and WCAIR Gilbert lab website Professor Nature. Unfortunately, melarsoprol-resistant parasites emerged as ea … See the complete profile on LinkedIn and discover David’s connections and jobs at similar companies. Welcome to Melanie Ridgway (from Australian Nat. The record includes the full address, along with information about the source of the data that will show whether the address is likely to be current. 112:9112-9117. Nucl. One goal is to understand the molecular mechanisms underlying this process. Acids Res. Wright Memorial Medal from the British Society for Parasitology. We recently identified >50 genes linked to drug action. “We reported our discovery of the VEX1 protein in 2016 and the VEX2 protein in 2019” he said. Genealogy profile for George Browne Provost of Dundee & Horn. On this page. Arsenicals were introduced as monotherapies for the treatment of human African trypanosomiasis, or sleeping sickness, over 100 years ago. 109:10996–11001. Professor David Horn FRSE Professor of Parasite Molecular Biology Antigenic variation, drug resistance and RNAi screens in trypanosomes : Professor Bill Hunter FRSE, FMedSci, FRSC Professor of Structural Biology Protein structure and function; fundamental chemical biology and early stage antimicrobial drug discovery : Dr Mattie Pawlowic Click here to find personal data about David Horn including phone numbers, addresses, directorships, electoral roll information, related property prices and other useful information. The University of Dundee’s Professor David Horn has received a prestigious award in recognition of his contribution to global efforts to overcome the disease known as African sleeping sickness. We also seek to understand drug action and resistance. USA. Consulting Engineer. Benzoxaboroles are under development for these lethal diseases and show great promise in clinical and veterinary trials. Horn Dand Cross GAM. SC015096. Current challenges include a shortage of safe, affordable, and efficacious drugs, as well as veterinary reservoirs of trypanosomes, which themselves cause livestock disease. The original oil paintings, watercolours and mixed media of the artist David Horn ARCA Art works. Aberdeen) and Douglas Escrivani (from Uni. Full Telephone: +44 (0) 1382 386286, int ext 86286. ), Marketa Novotna (Wellcome PhD), Gustavo Ruiz (from Uni. David has 11 jobs listed on their profile. The award recognises scientists who have made substantial contributions in the field of basic parasitology. Our research is supported by the Wellcome Trust and the Medical Research Council and DH is a Wellcome Trust Senior Investigator. Natl Acad. Proc. David Witteveen (born 5 May 1985 in Varese, Italy) is an Austrian footballer.He plays as a striker and is currently playing for SC Ritzing.. Career. Wright Memorial Medal from the British Society for Parasitology. Cells. Aberdeen) and Douglas Escrivani (from Uni. Alsford S, Turner DJ., Obado SO, Sanchez-Flores A, Glover L, Berriman M, Hertz-Fowler C and HornD. African trypanosomes are parasitic protists which cause sleeping sickness or Human African Trypanosomiasis (HAT) and the livestock disease, nagana. “We reported our discovery of the VEX1 protein in 2016 and the VEX2 protein in 2019” he said. The World Health Organization’s target is to stop sleeping sickness transmission by 2030. Professor David Horn, of the School of Life Sciences at the University of Dundee, is to be awarded the prestigious C.A. Horn, David Professor 取消收藏 收藏 完善纠错 ... University of Dundee School of Life Sciences ... Alsford S, Horn D. (2016) VEX1 controls the allelic exclusion required for antigenic variation in trypanosomes. Sci. Professor David Horn, of the School of Life Sciences at the University of Dundee, is to be awarded the prestigious C.A. [Click here for HMI-11 recipe and additional info']. Antigenic variation, drug resistance and RNAi screens in trypanosomes, School of Life Sciences, University of Dundee, Dundee, William Trager Award for Basic Parasitology (2019), Fellow of the Royal Society of Edinburgh (2017), Wellcome Trust Senior Investigator Award (2012), Wellcome Centre for Anti-Infectives Research (WCAIR), Parasite defence mechanism de-coded by Dundee research team, Award recognises ‘transformative’ research, £2.1 million Wellcome Investigator award for Dundee scientist, China Scholarship Council PhD programme - Anti-parasitic drugs: Mechanisms and protein modifications, MRC DTP: Understanding genetic mechanisms underpinning drug sensitivity in parasitic diseases, Wellcome 4-Year PhD Programme in Integrated Molecular, Cellular and Translational Biology. Baker N, Hamilton G, Wilkes J, Hutchinson S, Barrett MP, Horn D. (2015) Vacuolar ATPase depletion affects mitochondrial ATPase function, kinetoplast dependency and drug-sensitivity in trypanosomes. In particular, we have developed an RNAi library screening method called RNA Interference Target sequencing or RIT-seq. We also seek to understand drug action and resistance. Alsford S, Eckert S, Baker N, Glover L, Sanchez-Flores A, Leung K, Turner DJ, Field MC, Berriman M and Horn D.(2012) High-throughput decoding of antitrypanosomal drug efficacy and resistance. View the profiles of people named David Horn. USA.113:7225-30. Email (Sales and Technical) sales@dhcltd.co.uk. View the profiles of professionals named "David Horne" on LinkedIn. Nucleic Acids Res.39: 1372-1380. ), Marketa Novotna (Wellcome PhD), Gustavo Ruiz (from Uni. 10 11 * For correspondence: d.horn@dundee.ac.uk; Tel: +44 1382 386286 12 Welcome to Melanie Ridgway (from Australian Nat. One goal is to understand the molecular mechanisms underlying this process. Proc. DNA repair is required to replace the active Variant Surface Glycoprotein (VSG) gene with a new VSG and VSG expression is monoallelic (at a telomere) so our work in this area focuses on understanding mechanisms of DNA recombination and monotelomeric gene expression. Read reviews from current & past students for David Horn at University of Edinburgh. Cell 52:554-565. I use Lister 427, MITat 1.5 (clone 118a) and MITat 1.2 (clone 221a) (2, 3). A team at the University of Dundee has identified how random genetic decisions allow parasites to survive in their human and animal hosts. Random genetic decisions allow parasites to survive in their human and animal hosts at an in. Trypanosomiasis ( HAT ) and the VEX2 protein in 2019 ” he said a Horn living at address! Clinical and veterinary trials 1,000+ professionals named `` David Horne, P.E double-strand break repair in African trypanosomes management..., Sanchez-Flores a, glover L, Berriman M, Hertz-Fowler C and HornD MITat 1.5 ( 221a! 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